Increased expression of protease-activated receptor 1 (PAR-1) in human leukemias
نویسندگان
چکیده
منابع مشابه
Protease-activated receptor (PAR) 1 and PAR4 differentially regulate factor V expression from human platelets.
With the recent interest of protease-activated receptors (PAR) 1 and PAR4 as possible targets for the treatment of thrombotic disorders, we compared the efficacy of protease-activated receptor (PAR)1 and PAR4 in the generation of procoagulant phenotypes on platelet membranes. PAR4-activating peptide (AP)-stimulated platelets promoted thrombin generation in plasma up to 5 minutes earlier than PA...
متن کاملEvidence for increased expression of tissue factor and protease-activated receptor-1 in human esophageal cancer.
It has been suggested that the blood clotting initiator protein, tissue factor (TF), participates in tumor growth, metastasis and angiogenesis. In addition, a family of G protein-coupled-receptors known as protease-activated receptors (PARs) has also been implicated in tumor biology. These receptors might be activated by blood coagulation proteases thus eliciting a number of pro-tumoral respons...
متن کاملClinical significance of serum Protease-Activated Receptor-1 (PAR-1) levels in patients with cutaneous melanoma
BACKGROUND Protease-Activated Receptor-1 (PAR-1) plays an important role in the pathogenesis of multiple malignancies and its expression strongly also affects the outcomes of cancer patients. The objective of this study was to determine the clinical significance of the serum levels of PAR-1in cutaneous melanoma patients. METHODS A total of 60 patients with a pathologically confirmed diagnosis...
متن کاملProtease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis
Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease of unknown aetiology. Compelling evidence suggests that both protease-activated receptor (PAR)-1 and PAR-2 participate in the development of pulmonary fibrosis. Previous studies have shown that bleomycin-induced lung fibrosis is diminished in both PAR-1 and PAR-2 deficient mice. We thus have been suggested that...
متن کاملCardiovascular responses mediated by protease-activated receptor-2 (PAR-2) and thrombin receptor (PAR-1) are distinguished in mice deficient in PAR-2 or PAR-1.
We developed mice deficient in protease-activated receptor-2 (PAR-2) or PAR-1 to explore the pathophysiological functions of these receptors. In this report, we evaluated mean arterial pressure and heart rate (HR) changes in response to PAR-1 or PAR-2 activation in anesthetized wild-type (WT), PAR-1-deficient (PAR-1(-/-)), and PAR-2-deficient (PAR-2(-/-)) mice. In WT mice, TFLLRNPNDK, a PAR-1 s...
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ژورنال
عنوان ژورنال: Blood Cells, Molecules, and Diseases
سال: 2011
ISSN: 1079-9796
DOI: 10.1016/j.bcmd.2010.12.005